Optimal thought and optimal fitness through reason, logic, science, passion, and wisdom.
Caffeine Metabolism
Caffeine Metabolism

Caffeine Metabolism

In “2 Pharmacology of Caffeine” from “Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations” (Institute of Medicine (US) Committee on Military Nutrition Research.Washington (DC): National Academies Press (US); 2001, they write:

The mean half-life of caffeine in plasma of healthy individuals is about 5 hours. However, caffeine’s elimination half-life may range between 1.5 and 9.5 hours, while the total plasma clearance rate for caffeine is estimated to be 0.078 L/h/kg (Brachtel and Richter, 1992; Busto et al., 1989). This wide range in the plasma mean half-life of caffeine is due to both innate individual variation, and a variety of physiological and environmental characteristics that influence caffeine metabolism (e.g., pregnancy, obesity, use of oral contraceptives, smoking, altitude). …

Caffeine is rapidly and completely absorbed in humans, with 99 percent being absorbed within 45 minutes of ingestion (Bonati et al., 1982; Liguori et al., 1997). When it is consumed in beverages (most commonly coffee, tea, or soft drinks) caffeine is absorbed rapidly from the gastrointestinal tract and distributed throughout body water.

https://www.ncbi.nlm.nih.gov/books/NBK223808/

Leave a Reply

Your email address will not be published. Required fields are marked *